Abstract
Optical holograms can modulate light wavefronts to generate visible images. In the same way, acoustic images can also be synthesized by holograms, shaping the areas where mechanical waves present a high amplitude, and areas where the media is at rest. Acoustic holograms have found recent application in biomedical applications, in particular in emerging therapeutic applications of focused ultrasound. In this seminar, we will present the recent advances of acoustic holograms for the non-invasive treatment of neurological disorders. When targeting acoustic beams into the brain, accurate focusing is mainly limited due to the strong phase aberrations produced by the refraction and attenuation of the skull. Acoustic holographic lenses can overcome these limitations by synthetizing aberration-free ultrasonic fields of complex spatial distribution inside the skull. Our results show that, using low-cost 3D-printed lenses, ultrasonic beams can be focused not only at a single point, but overlapping at one or various target structures simultaneously, e.g., left and right hippocampi. Other complex fields such as vortex beams for trapping small objects can also be obtained. These results open new paths to spread emerging therapeutic ultrasound applications including blood-brain barrier opening or neuromodulation using low-cost systems.
BibTeX citation
@inproceedings{JimenezJASA2021Holograms,
author = {Noé Jiménez},
booktitle = {180th Meeting of the Acoustical Society of America, Acoustics in Focus. Online, 8 - 10 June},
editor = {The Journal of the Acoustical Society of America},
isbn = {ISSN: 0001-4966},
month = {06},
number = {4},
organization = {Acoustical Society of America},
pages = {A137},
publisher = {AIP Publishing},
series = {Invited},
title = {Tailoring therapeutic ultrasound beams with acoustic holograms},
volume = {149},
year = {2021}
}