Abstract
Focused ultrasound simultaneously applied with microbubbles is a non-ionizing technique for neurodegenerative diseases treatment allowing the opening of the blood-brain barrier locally, transiently, non-invasively and safely. In this paper, we numerically study the propagation of ultrasound beams across the human skull using a 500 kHz single-element focused transducer. Aberrations through different areas of the skull are assessed as a function of the distance and incidence angle between transducer-skull, the robustness of the system is evaluated and, finally, a protocol for Alzheimer’s treatment is developed using a custom semi-adaptive algorithm, achieving a 73% of covering of the human brain hippocampus.
BibTeX citation
@inproceedings{JimenezTEC2017,
author = {Sergio Jiménez-Gambín and Noé Jiménez and Miguel Company and Francisco Camarena},
booktitle = {Tecniacústica 2017: 48º Congreso Español de Acústica y Encuentro Ibérico de Acústica. La Coruña, Spain. 4 - 6 October},
doi = {http://www.sea-acustica.es/fileadmin/Coruna17/ULT-0%20015.pdf},
editor = {Conference proceedings},
month = {11},
organization = {Sociedad Española de Acústica},
pages = {1423-1431},
series = {Oral},
title = {Estudio numérico del protocolo de propagación transcraneal de ultrasonidos para la apertura de la barrera hematoencefálica en el hipocampo de humano},
url = {http://www.sea-acustica.es/index.php?id=768#c875},
year = {2017}
}