Efecto del método de definición de las propiedades acústicas de cráneo humano en la propagación focalizada de ultrasonidos

Abstract

Combination of focused ultrasound and microbubbles is a non-ionizing technique for neurodegenerative diseases treatment allowing the blood-brain barrier opening locally, transiently, non-invasively and safely. In this paper, we numerically study the effect in the propagation of ultrasound beams through a human skull which acoustical properties are obtained from a CT-scan using different methods. We use a single-element focused transducer working at 500 kHz. Aberrations through parietal bone are assessed, such us focus deviation and attenuation. The acoustic field distribution is also evaluated. Finally, the homogeneous model, which is the simplest one, generates higher focal attenuation, while the heterogeneous models offer a lower attenuation in the focal spot for the studied incidence skull area.

@article{Gambin2019a,
 author = {Sergio Jiménez-Gambín and Noé Jiménez and Francisco Camarena},
 doi = {http://www.sea-acustica.es/fileadmin/publicaciones/03_15.pdf},
 issn = {0210-3680},
 journal = {Revista de Acústica},
 month = {6},
 number = {1-2},
 pages = {22-25},
 title = {Efecto del método de definición de las propiedades acústicas de cráneo humano en la propagación focalizada de ultrasonidos},
 url = {http://www.sea-acustica.es/index.php?id=35&no_cache=1&tx_sfbooks_pi1[showUid]=9083&cHash=b559ffc28b655f5fe58c0d09a3914172},
 volume = {50},
 year = {2019}
}