Abstract
Design and test simple, low-cost acoustic holograms coupled to a single-element FUS transducer for aberration-free, highly-localized, simultaneous, multiple BBB-opening in both brain hemispheres in mice. This study demonstrates that acoustic holograms are feasible to produce a high-resolution, simultaneous bilateral BBB opening in mice using a single sonication and injection of microbubbles, as well as in different animals using a separate unique micro-CT scan, defining therefore a time- and cost-efficient therapeutic approach for neurological disease treatments.
BibTeX citation
@inproceedings{GambinISTU2022holograms,
author = {Sergio Jiménez-Gambín and Antonios N. Pouliopoulos and Noé Jiménez and José M. Benlloch and Elisa E. Konofagou and Francisco Camarena},
booktitle = {ISTU 2022: 21th International Symposium for Therapeutic Ultrasound. Toronto, Canada. 7 - 10 June},
editor = {Conference proceedings},
isbn = {ISBN: 978-84-87985-30-4},
month = {6},
organization = {International Society for Therapeutic Ultrasound},
publisher = {European Focused Ultrasound Charitable Society},
series = {Oral},
title = {Acoustic Holograms for Bilateral Blood-brain Barrier Opening in Mice},
year = {2022}
}